Jobbörse

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Postdoc position in Human Reproduction Genetics in Heidelberg

(Eintrag vom 20.02.2018, aktualisiert am 02.03.2018)

“Molecular control signature of FMR1/FMRP expression in human granulosa cells functional during folliculogenesis and for ovarian reserve” 

Research projects in my research group (AG “Genetics of Human Folliculogenesis”) at Division of Reproductive Genetics (head: Prof. Dr. P.H. Vogt) are concentrated on the molecular analysis of genetic and epigenetic regulatory mechanisms controlling FMR1/FMRP expression during human folliculogenesis and its putative distortion in some well-known female germ line disorders such as Premature Ovarian Insufficiency/Failure (POI/POF) syndrome and Poor Ovarian Response (POR). Our aim is to identify the molecular tools functional in genetic germ line networks as the mTOR/AKT/FOXO signal pathway associated with the regulation of FMR1/FMRP expression in the female germline cells (oocytes, granulosa cells, theca cells). Our results will help not only to understand much better how these genes/proteins impact human female fertility, but also to develop novel starting points for improved molecular diagnostic and therapeutic tools for infertility treatment and assisted reproductive techniques (ART).

Related Publications:

  • Genetische Ursachen der prämaturen OvarialinsuffizienzRehnitz J, Strowitzki T, Vogt PH. Gynäkologische Endokrinologie. Ausgabe 04/2018
  • The FMR1 gene, infertility, and reproductive decision-making: a review.Pastore LM, Johnson J.; Front Genet. 2014 Jul 7;5: 195. Review
  • Variable expression of the Fragile X Mental Retardation 1 (FMR1) gene in patients with prematureovarian failure syndrome is not dependent on number of (CGG)n triplets in exon 1. Schuettler J,Peng Z, Zimmer J, Sinn P, von Hagens C, Strowitzki T, Vogt PH: Hum Reprod. 2011May;26(5):1241-1251.
  • FMR1 and AKT/mTOR signaling pathways: potential functional interactions controllingfolliculogenesis in human granulosa cells. Rehnitz J, Alcoba DD, Brum IS, Hinderhofer K, YounessB, Strowitzki T, Vogt PH. Reprod Biomed Online. 2017 Nov;35(5):485-493.

Your profile

  • PhD degree in molecular biology, biochemistry or equivalent (preferable but not essential with topic centered in Human Reproduction Biology)
  • Splendid expertise in all molecular biology techniques and extensive experience in human cell culture work. Especially: Western blotting, Immunoprecipitations, ChIP, gene expression analysis, PCR, qPCR, cloning, sequencing, ELISA, Fluorescent microscopy, Next-Generation-Sequencing, CRISPR/CAS9, shRNA- mediated knock down techniques
  •  Excellent personal communication and organization skills (in German & English language)
  • Extensive experience in the analysis of complex molecular data using NCBI and ENSEMBL and similar data bases.
  • Broad knowledge with ADOBE/COREL DRAW graphic programs, statistical software and bioinformatics online tools (TRANSFAC, CLUSTAL, BLAST, etc).
  • English (written and spoken) for publication work, participation in distinct student supervision work for Bachelor and Master research projects & research internships

Contact & Application

Application should be submitted per mail or e-mail as one single PDF-file (max 5 MB) to
Dr. Julia Rehnitz (julia.rehnitz@med.uni-heidelberg.de).
Please include an extensive motivation letter, your scientific CV, academic certifications
including complete list of publications; 2-3 references of your past supervisors and give
your expected availability date.

Please do not send original documents by mail services, since they will not be returned.

For further information you may like to contact: Julia.rehnitz@med.uni-heidelberg.de

Das pro-Kindwunsch Kinderwunschzentrum Niederrhein in Mönchengladbach sucht Verstärkung

(Eintrag vom 06.11.2018)

Das pro-Kindwunsch Kinderwunschzentrum Niederrhein in Mönchengladbach (www.pro-kindwunsch.de) sucht ab sofort

eine/n engagierte(n) Vollzeit-MTA-/BTA

gerne auch ohne Erfahrung in der Reproduktionsmedizin.

Die Tätigkeiten umfassen Aufgaben auf den Gebieten der Andrologie und Reproduktionsbiologie (IVF/ICSI).

Die vertrauliche Bearbeitung Ihrer Bewerbung wird Ihnen versichert.

Es erwartet Sie ein abwechslungsreiches und interessantes Tätigkeitsfeld mit vielen Gestaltungsmöglichkeiten.

 

Bewerbungen bitte per Mail an: info@pro-kindwunsch.de

oder postalisch an

pro-Kindwunsch Kinderwunschzentrum Niederrhein
Dr. med. Georg Döhmen
Von-Groote-Straße 175
41066 Mönchengladbach

The German Primate Center GmbH – Leibniz-Institute for Primate Research is looking for support

(Eintrag vom 24.05.2018)

The DPZ Platform Degenerative Diseases (Head: Prof. R. Behr) will intensify its current research activities in the fields of embryology, assisted reproductive technologies and stem cell research in the context of the DZHK focus on cardiovascular research and heart regeneration. Therefore, we are seeking for a

postdoc / scientist (f/m)

The candidate (PhD, MD, Veterinarian or equivalent) should be highly motivated to refine and further develop assisted reproductive technologies in nonhuman primates.

Practical work with monkeys in collaboration with a veterinarian is part of the work.

 

Please send in your application as a single pdf file or as hardcopy including all certificates
until the 25th of May under key word “Assisted Reproduction – Scientist or Technician” to

Deutsches Primatenzentrum GmbH
Leibniz Institut für Primatenforschung
Personnel Office
Kellnerweg 4
37077 Göttingen

or via mail to bewerbung@dpz.eu

Further information can be found in the job ad.